2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. 5-HT Receptor

5-HT Receptor

Serotonin Receptor; 5-hydroxytryptamine Receptor

5-HT Receptor

Related Products

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5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. Type: 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7. They mediate both excitatory and inhibitory neurotransmission. The serotonin receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand. The serotonin receptors modulate the release of many neurotransmitters, as well as many hormones. The serotonin receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, andthermoregulation. The serotonin receptors are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, anorectics,antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens.

5-HT Receptor Isoform Specific Products:

5-HT Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-103130A
    EMD 386088 free base
    		Agonist
    EMD386088 free base is a potent serotonin 6 receptor (5-HT6R) agonist. EMD386088 free base induces cell death. EMD386088 free base regulates the activity of ERK1/2. EMD386088 free base has the potential for the research of alzheimer's disease (AD) and schizophrenia.
    EMD 386088 free base
  • HY-169786
    5-HT2A receptor agonist-5
    		Agonist
    5-HT2A receptor agonist-5 (compound I-3) is a potent 5-HT2A receptor agonist with a Ki value of 0.017 µM. 5-HT2A receptor agonist-5 shows antidepressant activity.
    5-HT2A receptor agonist-5
  • HY-103098
    EMDT oxalate
    		Agonist
    EMDT oxalate is a selective 5-HT6 agonist, and has antidepressant effects.
    EMDT oxalate
  • HY-180185
    5-HT2A&5-HT2C agonist-2
    		Agonist
    5-HT2A&5-HT2C agonist-2 (Compound 3ci) is a highly selective dual 5-HT2A/5-HT2C agonist that can cross the blood-brain barrier and has an EC50 < 1 μM. 5-HT2A&5-HT2C agonist-2 has high selectivity for 5-HT2B related to the risk of heart valve disease. 5-HT2A&5-HT2C agonist-2 can induce head convulsive responses, but has a relatively low hallucinogenic potential. 5-HT2A&5-HT2C agonist-2 can be used in the research of diseases such as depression and obesity.
    5-HT2A&5-HT2C agonist-2
  • HY-121653B
    Flesinoxan hydrochloride
    		Agonist
    Flesinoxan hydrochloride is a hypotensive agent and a potent, high affinity and selective 5-hydroxytryptamine1A (5-HT1A) receptor agonist with an EC50 value of 24 nM. Flesinoxan hydrochloride also has effective anxiolytic/antidepressant effects.
    Flesinoxan hydrochloride
  • HY-135493
    RS-56812
    		Agonist
    RS-56812 is a partial agonist of the 5-HT3 receptor. RS-56812 significantly enhances the propulsive peristalsis of the colon. RS-56812 indirectly enhances cholinergic neurotransmission and improves the working memory performance of non-human primates. RS-56812 is used in research on diarrhea/colon peristalsis and cognitive disorders (such as Alzheimer's disease).
    RS-56812
  • HY-157429
    25N-N1-Nap
    		Agonist
    25N-N1-Nap (compound 16) is a β-arrestin-biased 5-HT2A agonist. 25N-N1-Nap antagonizes phencyclidine induced hyperactivity in Male C57BL/6 J mice.
    25N-N1-Nap
  • HY-19372
    SSR-181507 hydrochloride
    		Agonist
    SSR-181507 hydrochloride is a dopamine D2 receptor antagonist and 5-HT1A receptor agonist. SSR-181507 antagonizes Apomorphine (HY-12723)-induced climbing in mice and stereotypies in rats. SSR-181507 hydrochloride can be used in the research of depression and anxiety.
    SSR-181507 hydrochloride
  • HY-145841
    5-HT2A receptor agonist-2
    		Agonist
    5-HT2A receptor agonist-2 is a highly potent serotonin 5-HT2 receptor agonists. 5-HT2A receptor agonist-2 inspires 5-HT2A, 5-HT2B, and 5-HT2C with EC50 values of 1.7, 0.58, and 0.50 nM, respectively.
    5-HT2A receptor agonist-2
  • HY-105192
    CP-122288
    		Agonist
    CP-122288, a highly potent inhibitor of neurogenic inflammation, can be used in migraine study.
    CP-122288
  • HY-B0206R
    Rizatriptan benzoate (Standard)
    		Agonist
    Rizatriptan (benzoate) (Standard) is the analytical standard of Rizatriptan (benzoate). This product is intended for research and analytical applications. Rizatriptan benzoate is the agonist for 5-HT1B and 5-HT1D. Rizatriptan benzoate has a peripheral vasoconstrictive effect, penetrates the intact blood-brain barrier, and inhibits pain neurotransmission in the central nervous system.
    Rizatriptan benzoate (Standard)
  • HY-103151A
    CP94253
    		Agonist
    CP94253 is an orally active, brain-penetrant and selective 5-HT1B receptor agonist with an Ki of 2 nM. CP94253 induces antidepressant-like effects, waking enhancement, sleep inhibition, increased sleep latency, hyperlocomotion, and suppressed aggressive behavior. CP94253 can be used for the research of depression and heightened aggressive behavior.
    CP94253
  • HY-105082
    Avitriptan
    		Agonist
    Avitriptan is a 5-HT1B/1D receptor agonist, with pKis of 7.44 ( 5-HT1B rat), 7.68 ( 5-HT1B human) and 8.36 ( 5-HT1D human). Avitriptan constricts the isolated coronary artery. Avitriptan can be used for migraines.
    Avitriptan
  • HY-100426A
    Osemozotan hydrochloride
    		Agonist
    Osemozotan hydrochloride (MKC242) is a selective 5-HT1A receptor agonist. Osemozotan hydrochloride decreases the number of c-Fos-positive cells caused by MAMP in mice. Osemozotan hydrochloride can be used for the research of depressive disorder.
    Osemozotan hydrochloride
  • HY-163205
    VU6067416
    		Agonist
    VU6067416 is a potent and brain-penetrant 5-HT2A agonist with an EC50 of 189 nM.
    VU6067416
  • HY-B0716S2
    Urapidil-d4
    		Agonist
    Urapidil-d4 is the deuterium labeled Urapidil. Urapidil is an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist.
    Urapidil-d<sub>4</sub>
  • HY-101357
    CP 93129
    		Agonist
    CP 93129 is a potent and selective 5-HT1B agonist. CP 93129 has the potential for the research of Parkinson's disease.
    CP 93129
  • HY-108227
    Quetiapine sulfone
    		Agonist
    Quetiapine sulfone is a main metabolite of Quetiapine (HY-14544). Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist.
    Quetiapine sulfone
  • HY-121249
    Capeserod hydrochloride
    		Agonist
    Capeserod hydrochloride (SL65.0155) is a 5-HT4(e) receptor partial agonist (Ki=0.6 nM) with potent cognitive enhancing properties. Capeserod hydrochloride acts as a partial agonist in cells expressing 5-HT4(b) and 5-HT4(e) splice variants, stimulating cAMP production with IC50 values of 244 and 29 nM, respectively. Capeserod hydrochloride is used in the study of memory impairment and dementia.
    Capeserod hydrochloride
  • HY-116524
    PF-04781340
    		Agonist
    PF-04781340 is a potent and selective 5-HT2C receptor agonist. PF-04781340 is orally available and have central nervous system penetrant profile.
    PF-04781340
Cat. No. Product Name / Synonyms Application Reactivity
5-HT Receptor Isoform Comparison

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